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附子가 6-propyl-2-thiouracil(PTU)로 유발된 rat의 갑상선 기능저하증에 미치는 영향 게시글 내용
제목 附子가 6-propyl-2-thiouracil(PTU)로 유발된 rat의 갑상선 기능저하증에 미치는 영향 2013-06-03

The Effects of Aconiti Radix on Thyroid Function in Hypothyroidism Rat Model Induced by 6-propyl-2-thiouracil(PTU).

Sang-hun Lee, Byung-cheol Lee, Young-min Ahn, Ho-kyung Doo, Se-young Ahn
Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Korea.

ABSTRACT
Objective : Although hypothyroidism is a common disease in the endocrinology system, it is reported that there are a lot
of difficulties in treating it effectively. Aconiti Radix traditionally has been used in treatment of coldness, fatigue, and
bradycardia. In this study, we investigated the therapeutic effects of Aconiti Radix on hypothyroidism rat model induced by
6-propyl-2-thiouracil (PTU).
Methods : Two-month-old rats were used with administration of PTU which induced hypothyroidism in the rats. After 2
weeks, Aconiti Radix and thyroxine were administered, respectively. The body weights were measured every week. After 4
weeks, the blood samples of all rats were taken from their hearts. They were analyzed biochemically and T4 (thyroid hormone)
& TSH (thyroid stimulating hormone) was measured by ELISA kits.
Results : In comparison with normals, controls showed hypothyroidism with significantly low T4 and high TSH the
statistics. In Aconiti Radix administration groups significantly increased T4 was observed in the statistics and its effects were
dose-dependent. There was no difference statistically in TSH of Aconiti Radix treatment groups from controls, nor were
statistical differences observed significantly in biochemical labs and weight of each group.
Conclusions : These findings suggest that Aconiti Radix protects thyroid cells and makes thyroid cells produce thyroid
hormones. It is also very safe in the view of liver, kidney function, and other metabolism. It may be a useful agent for
treating hypothyroidism.
Key words : Aconiti Radix, 6-propyl-2-thiouracil(PTU), Hypothyroidism.
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177번 게시글의 이전글, 다음글
이전글 세무·법률 자료실 乾薑이 PTU로 유발된 Rat의 갑상선 기능저하증에 미치는 영향
다음글 세무·법률 자료실 한방병원 갑상선 클리닉 내원 환자들의 임상적 특성 분석

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  • 대구광역시 수성구 지범로 59,4층 406호
  • 본 웹사이트에서는 이메일주소가 무단 수집되는 것을 거부하며, 위반 시 정보통신법에 의해 처벌됨을 유념하시기 바랍니다.
  • Copyright (C) 2013 KOREAN M.D AND O.M.D ASSOCIATION. All rights reserved.